It happened at 1:21 a.m. Sunday in the 2300 block of Pennsylvania Avenue.
Investigators say a Dodge Caravan was travelling westbound on Pennsylvania when it crossed the path of Hyundai Santa Fe that was travelling eastbound.
The front seat passenger in the Caravan was killed.
Investigators say charges are pending following an investigation.
Anyone with information is asked to call police at (302) 576-3692.