"The Twilight Saga: Eclipse," TV's "House M.D." and Eminem each won four awards at Wednesday's ceremony, hosted by Queen Latifah at the Nokia Theatre in downtown Los Angeles.
Fans picked "Twilight" as their favorite overall movie and favorite drama. Stars Kristen Stewart, Robert Pattinson and Taylor Lautner were their favorite on-screen team, and Stewart also won actress honors.
Johnny Depp was fans' favorite actor, Jackie Chan won for action star, Adam Sandler won for comedic star, and "Toy Story 3" was voted favorite family movie.
"House M.D." was TV's top winner. The show was fans' favorite television drama, and stars Hugh Laurie and Lisa Edelstein were the favorite actor and actress in the drama category. Laurie's character, Gregory House, was named favorite TV doctor.
"Glee" was voted top TV comedy, and star Jane Lynch was the favorite comedy actress. Neil Patrick Harris won comedy actor honors.
Eminem dominated the music category. He was fans' favorite hip-hop artist and male musician, and his song with Rihanna, "Love the Way You Lie," won favorite song and music video. Katy Perry was a double winner: Favorite female artist and favorite online sensation.
Rihanna, Usher and Taylor Swift were named favorite pop, R&B and country artist, respectively.
Fans chose the winners in all categories.