WHIO-TV says about 70 firefighters were called out shortly before 4 a.m. Tuesday to fight the fire near Versailles.
The barn is on a farm owned by Kissinger Brothers Poultry and was fully engulfed when firefighters arrived. Fire officials say the barn was a total loss and estimate damage at about $1.5 million.
Authorities say the cause of the fire is under investigation.
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Information from: WHIO-TV