WHIO-TV says about 70 firefighters were called out shortly before 4 a.m. Tuesday to fight the fire near Versailles.
The barn is on a farm owned by Kissinger Brothers Poultry and was fully engulfed when firefighters arrived. Fire officials say the barn was a total loss and estimate damage at about $1.5 million.
Authorities say the cause of the fire is under investigation.
Information from: WHIO-TV