It happened around 2:00 Sunday morning near the intersection of 17th and Federal streets.
A preliminary investigation revealed that the victim was confronted by an unknown male who opened fire.
The victim - a man in his 20s - tried to get away, running inside a home on the 1500 block of Federal Street.
Gunfire struck the victim in the chest. He was taken to Jefferson Hospital where he was later pronounced dead.
No word on the victim's identity.
An investigation continues.