It happened around 3:00 Sunday morning at the pharmacy on Welsh Road.
Police tell Action News that this same Rite Aid was robbed twice back in May.
Authorities say in the most recent incident, three men entered the store and ordered the security guard down to the floor.
According to police, one of the masked men held the guard down with his foot and pointed a gun at him.
A second masked man ordered a patron to the floor and robbed him of his wallet.
A third man pointed a gun at the clerk and ordered her to open the safe and hand over the money.
All three suspects fled the store with an undisclosed amount of money and no one was injured.
Detectives are hoping to view security video from the store.