New Jersey State Police say the crash occurred just after 10:00 a.m. Thursday at milepost 39.9 in Mount Laurel and involved two tractor-trailers and two passenger vehicles.
Three people were killed in the crash. A fourth person suffered minor injuries.
Southbound traffic was being diverted off the turnpike at Exit 7-A while crews worked to clear the scene. All lanes have since reopened.
The cause of the accident is under investigation.