Jeffrey Vipond, 64, of the unit block of Scarborough Drive in the Mill Creek Village Apartments, has not been seen since 11:00 p.m. Thursday.
Vipond is 6'1" tall, 200 pounds, with hazel eyes and gray/white hair. He was last seen wearing a tan jacket, blue jeans and black boots.
Police say his medical status is such that there is a real concern for his welfare.
This isn't the first time Vipond has vanished. In 2010, he was reported missing and was eventually found in Scranton, Pa.
Anyone with information is asked to contact the New Castle County Police Department at (302) 573-2800.