Acting on a tip late Wednesday night, Delaware State Police and drug agents from the Kent County Governor's Task Force descended on the Super 8 Hotel on Bay Road north of Milford.
Police raided room number 210 and found more than 400 bundles of heroin, dozens of prescription drugs, marijuana, 2 handguns, and more than $1100 in suspected drug money.
They also found a three-year-old child in the room.
Arrested were Melissa Summers, 27, of Houston Delaware, who was wanted on an outstanding warrant; Jemal Greene, 39, of Dover, Delaware; Megan Maloney, 19, of Harrington, Delaware; and Robin Walls, 24 of Harrington, Delaware.
All four were charged with drug and weapons offenses and endangering the welfare of a child.
All are now behind bars on bail amounts ranging from $41,000 to $61,500.
The child was turned over to relatives at the scene.