The shooting happened shortly after 10:00 p.m. on the 2600 block of North Claymont Street.
Arriving police officers and medics worked feverishly on the victim, who had sustained a gunshot wound to the neck and chest.
The man, identified as 27-year-old Marvin Moore, was transported to Christiana Care Health System where he later died.
So far, there is no word on a suspect or motive.