In a statement posted on their website, station management said Collins passed away just after midnight at Chestnut Hill hospital after suffering a heart attack.
The statement went on to say Collins was surrounded by family and friends.
He was 58 years old.
Reflecting on his life and career, the 100.3 statement read, in part:
"E. Steven Collins' legacy transcends anything written in a biography or press clipping, and his name is by far one of the most well-known and respected names in Philadelphia broadcasting with a distinguished thirty-year history headlined by his passionate devotion to the community. Influence, power, esteem, loyalty, and respect all rolled up into one capital letter, "E." as the world knew him best."
"Collins devoted the past decade of his as Radio One's Director of Urban Marketing and External Relations and the host of his weekly show, Philly Speaks on Old School 100.3 which regularly featured a distinguished panel of local & national guests each Sunday."
Collins is survived by his wife, Lisa, and sons Rashid and Langston.
Read the statement from 100.3 FM on their website.