The incident occurred around 5:30 a.m. where several people were camped outside the Sneaker Villa at 6th and Market Streets.
The two males were waiting for the release of six different types of Air Jordan sneakers when they got into an argument.
Police say gunfire erupted during the fight and both males were struck.
They were taken to Wilmington Hospital and later transferred to Christiana Hospital.
One of the victims is in critical condition.
So far, no arrests have been made.
The victims have not been identified.