A man told police he found the remains Monday in a locked footlocker while cleaning out his deceased mother's home in North Canton, about 45 miles southeast of Cleveland.
The Stark County coroner's office confirmed the remains were those of two infants. It's not clear how old the remains are or how old the woman was.
Investigators have searched the home but found nothing else noteworthy.
The coroner's office plans to have forensic anthropologists in Pennsylvania examine the remains.