It happened at 8:00 p.m. Sunday at the intersection of Limekiln Pike and Ogontz Avenue.
Authorities say the outer wall of a vacant home collapsed. Two people walking by at the time were hurt.
It appears they were hit by flying debris.
Witnesses say they were conscious and speaking when medics took them to Albert Einstein Medical Center for evaluation.
The victims were listed in stable condition.
Action News spoke to area resident who stepped in to help one of the injured. Michael Scott said he was in a nearby apartment when he felt rumbling.
"Boom! I mean, it shook my apartment," said Scott. "I live right behind the building, so it shook my apartment. And that's why they told me to get out, because they were worried that the building was going to continue fall onto our apartment."
The fire department's Operations Unit searched the rubble but didn't find anyone there.
The scene has been turned over the L&I.
The cause is under investigation.