It happened around 9:30 Saturday night on Route 273 at I-95.
Police say the male driver lost control of his vehicle in the westbound lanes.
The vehicle went up an embankment and struck the I-95 overpass.
The driver was pronounced dead at the scene. A female passenger was taken to Christiana Hospital in critical condition.
No word what caused the driver to lose control.
Delaware State Police are investigating.
