Well, if Garnet Valley's record so far is any indication, there is no nervousness to be found.
This year marked Garnet Valley's induction as a member of the Central League, home to, yes, Conestoga for many, many years.
Since the beginning of the season, many were wondering how would Garnet Valley fare in its new surroundings. Would they be able to repeat their past state final season performances?
Week 1 saw the Jaguars take on another new Central League recruit in the form of Harriton. Garnet Valley walked away with a clean 42-6 victory.
The next week GV defeated Penncrest 37-21. They followed that up with victories over Marple Newtown, 41-13, and Strath Haven 27-17.
So far so good for the Jaguars, but this is Conestoga we're talking about.
"This is the first time we've ever played Conestoga, but I know they've been a great team and they've been one of the top teams in the Central League year in and year out," Garnet Valley Head Coach Mike Ricci said.
Last season, Conestoga went to the second round of the playoffs and on the route there they were part of the inaugural season of the 6abc Game of the Week.
Unfortunately for all the Pioneer players and fans, they lost to Strath Haven.
This season, they could not get past Strath Haven again, nor Ridley, as they were shut out in both games.
The Pioneers started this season, though, the right way, with wins over Marple Newtown, 21-6, and Lower Merion, 24-0.
Now, they have the Jaguars breathing down their necks and they know it.
"Garnet Valley's an outstanding football program. You're talking about a state final caliber team coming in this year to the Central League," Conestoga Head Coach John Vogan.
The match is set.
For the first time ever, anywhere, the Pioneers meet the Jaguars on 6abc.com.
Conestoga is ready to reverse their bad luck of the previous two weeks.
Garnet Valley is ready to prove to all they can make it in the Central League.
Both teams are ready to seize the moment.