A-Rod hit a disputed drive in the right-field corner that clanked off the lens of a TV camera above the wall at Citizens Bank Park.
Rodriguez, who also homered in the first regular-season use of replay last year, hit an opposite-field shot with the Yankees trailing Philadelphia 3-0 in the fourth inning.
Mark Teixeira was on first base with one out when Rodriguez sent an 0-1 pitch down the line off Cole Hamels, and the ball bounded back on the field. Rodriguez stopped at second base, with Teixeira holding at third, and A-Rod signaled home run with his hand.
After Yankees manager Joe Girardi came out, the umpires convened and then went inside to check replays as Rodriguez spoke with Phillies first baseman Ryan Howard, who had trailed him to second on the play. About 1 minute later, they emerged and signaled home run, bringing New York within a run and prompting the crowd to boo.
Baseball began employing video review starting in August 2008, with the umpires consulting replays shown from a control center at Major League Baseball Advanced Media in New York.
In its first use, a home run by Rodriguez at Tampa Bay was upheld on Sept. 3, 2008. This was the first-ever use of technology in a postseason game.
FOX had 20 cameras covering Saturday night's game, and their positions were approved by Major League Baseball and the umpires, network spokesman Lou D'Ermilio said.
Rodriguez's sixth postseason homer tied New York's postseason record, set by Bernie Williams in 1996. It stopped an 0-for-8 Series slide for Rodriguez that included six strikeouts and was the Yankees' team-record 17th homer of the postseason, one more than they hit in 1996, 2001 and 2003.
All five previous home runs in this year's Series had been solo shots. Nick Swisher and Hideki Matsui homered for the Yankees later in the game.
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