The crash happened just after midnight, on I-95 south, near Exit 9 in Tinicum Township.
State Police say 30-year-old Ty Granberry of Twin Oaks, Pennsylvania, and two other bikers were weaving in and out of traffic at a very high rate of speed, when Granberry tried to change lanes.
That's when his bike fishtailed.
He was thrown from the motorcycle and killed.
The riderless bike slammed into a 2009 Nissan Murano then struck a guardrail and burst into flames.
Police could not immediately determine the make of the bike because it was burned beyond recognition.
The Nissan sustained only minor damage.
The driver, 67-year-old Judith Enterline of York Pennsylvania, was wearing a seatbelt and was not injured.
Another bike rider, 29-year-old David Choung of Elkins Park, saw the accident, and tried to come to a quick stop, but ended up also losing control of his motorcycle.
Choung's bike also crashed into the guardrail.
He was also thrown from his bike, but managed to walk away from the accident without suffering any injuries.
Both bikers were wearing helmets.