Thomas says the site, which officially launched Wednesday, is aimed at woman over 35 years old.
The well-known actress and social activist says the goal is for her to talk to the nation's women - and get them talking back.
She says she wants women to feel "there's lots of dreaming yet to go."
She describes the site as video-heavy, including live streaming chat and user-submitted video, and says she wants to share ideas.
Next week, Thomas is releasing a memoir, "Growing Up Laughing."
Earlier this month, AOL added talk-show host Ellen DeGeneres to its Web properties as it began sharing content with the website of "The Ellen DeGeneres Show."