Lou Williams scored 13 of his 19 points in the fourth quarter for Philadelphia, which placed seven players in double figures in its highest scoring output of the season. Jodie Meeks and Jrue Holiday had 16 points apiece, Andre Iguodala scored 13 and Elton Brand finished with 12.
J.J. Hickson had 18 points for Cleveland, which has lost five consecutive games by an average of 22.2 points. Daniel Gibson scored 16 and Mo Williams added 15.
Young made 11 of 12 shots from the field and also had 11 rebounds as the Sixers bettered their previous scoring high set in a 123-116 loss to the Cavaliers on Nov. 3. He scored 17 of Philadelphia's 66 first-half points, a team high for any half this season.
Cleveland has dropped nine of 11 overall, surrendering at least 100 points in each of those losses.
After a slow early start, Philadelphia (7-14) found its shooting touch against one of the league's worst defenses, shooting 26 of 46 from the floor and 11 of 15 from the free-throw line to build a 66-54 lead at halftime.
Cleveland (7-14) stumbled in the third quarter and Spencer Hawes made a 3-pointer with 2:27 left to increase Philadelphia's lead to 89-66.
The Cavaliers pulled within 11 early in the fourth quarter on Gibson's 3-pointer, but the Sixers responded with a 14-4 run.
NOTES: With 10 points and 12 rebounds, Hawes recorded his first double-double of the season. ... Meeks made his third straight start since replacing Evan Turner, the No. 2 overall pick, in the starting lineup. He scored a career-high 26 points on Dec. 4.