The crash happened just after midnight along the 2100 block of East Butler Avenue.
Police say the driver of a Honda collided with another vehicle near the intersection of Sepviva Street.
When firefighters arrived they found two men trapped inside the Honda.
The men were freed and transported to a local hospital, where one of them is in critical condition.
Four people in the other vehicle were also injured. They were transported to area hospitals, listed in stable condition.
Police are still trying to piece together exactly what caused the crash.
At this time no one has been charged.