The Grammy-winning singer will visit the Professional Performing Arts School in Manhattan on Tuesday and donate music instruments to its students.
Keys says her alma mater is underfunded and oversubscribed, "and I hope to make this better for them."
She will also launch an online contest where people can share how they would use $1,000 "to make the world a better place." It is part of the global campaign, "World of Betters."
The contest begins Tuesday and ends Dec. 15.
"World of Betters" also features rapper K'Naan, who will host an event in Johannesburg, and Indian singer Sunidhi Chauhan, who will host an event in Mumbai, India.