The 2-alarm fire broke out shortly before 5:30 a.m. on the first floor of a row home on the unit block of Race Street.
Police say several residents could not get out the front door and escaped the fire by jumping from the second floor.
Two residents were taken to a local hospital and treated for non-life threatening injuries.
The fire was placed under control just after 6:30 a.m.
Trenton fire officials told Action News, there is no exact cause of the blaze but the fire appears to be ''accidental."
The blaze destroyed two other row homes on the street.