The burglary happened sometime between Monday and Friday at Jackson's home on the 3200 block of Pietro Way.
Detectives say Jackson's mother made the discovery Saturday. There was no forced entry and Jackson himself was away at the time.
According to police, the thieves broke into a couple of safes stealing a handgun, cash and jewelry, most of which were high-end watches.
Jackson is offering the reward for information leading to an arrest and conviction of the person(s) responsible.
Through his spokesperson, Jackson released the following statement Sunday:
Desean is clearly upset that his home was burglarized while he was out of town on vacation. He has always felt very safe in his community and it concerns him someone would victimize his place of residence. He had personal items, jewelry and a small amount of money taken in the burglary, however the amount that has been previously reported is inaccurate. The large sum that was taken was in items. He thanks everyone for their concerns and he is confident the Philadelphia Police Department will find the suspects at large.
"Wow there could be a million people that could target him because he is so popular. If I tell anyone I live next to Desean Jackson, then a million questions start coming after that," said Lina Arici, neighbor.
Arici, who says her high profile neighbor keeps to himself, was surprised considering the security in the community.
"Literally every hour you'll see them walk by the house, walk behind, walk in the front. If there are ever any issues, they will knock on the door and make sure everything is okay," she said.
No word on any suspects at this time.