Chester police officers were called around 10:45 p.m. Saturday to the 500 block of Highland Avenue for a shooting.
Upon arrival, police discovered a 38-year-old male suffering from multiple gunshot wounds to the head, neck and chest.
Paramedics transported the victim to Crozer Chester Medical Center where he was later pronounced dead.
This victim's name is being withheld until additional family members can be notified.
A second male, age 23, also struck by the gunfire was taken to Crozer Chester by private vehicle with chest and wounds to his left arm.
Chester and County detectives responded to assist in the investigation.
Anyone with information can contact Chester Police Detective Patrick Mullen at (610) 447-7813 or CID Detective Edward Kazlo (610) 891-4710.