It happened around 7 a.m. Wednesday at the intersection of South College Avenue (SR 896) and West Chestnut Hill Road.
The driver is identified as 55-year-old Thomas Polis of Newark.
Polis was behind the wheel of a Chrysler Sebring when he collided, head on, with the bus.
He died at Christiana Hospital.
Six passengers from the Dart bus were examined for possible injuries.
The investigation into the cause of the accident is ongoing.
Send a News Tip to Action News
Learn More About 6abc Apps