It happened on the southbound lanes of the highway near Exit 9 in Tinicum Township.
Around 5:30 p.m. police found a driver who crashed into the guard rail in the southbound lanes of the highway.
Upon further investigation, the driver, who sustained a gunshot wound, was found dead at the scene, said police.
Chopper 6 was over the wreck as police diverted southbound traffic onto the northbound lanes.
Police are still investigating the circumstances surrounding the incident.
Anyone with any information is asked to call police at 484-840-1000.