Jose Diaz, 31, and his 3-year-old daughter Leih Diaz were reported missing from a residence in the Clementon section of the township around 9 p.m. Wednesday.
Police said they were last seen leaving the area in a 2014 burgundy Honda Accord.
Investigators believe they may be headed to the Bronx, New York.
Jose Diaz is described as a Black male, 5'9 tall, 250 pounds, with brown eyes and brown hair. He was last seen wearing a black or dark-colored jacket.
Leih Diaz is a 3-year-old Hispanic female with brown eyes and brown hair. She was last seen wearing a black jacket and blue jeans or tan pants.
Anyone with information should contact the Gloucester Township Police Department at 856-228-4500 or call the GTPD Anonymous Tip Line at 856-842-5560.