Chopper 6 was over the scene on Street Road near Pickering Road just after 9 p.m.
Authorities said the operator of the motorcycle, Maryan Romanyk, 26, of Philadelphia, was killed in the crash.
Two people in the SUV were transported to Abington Hospital.
Street Road was closed until 1 a.m. while authorities investigated the accident.
Any witnesses are asked to call Upper Southampton Township Police Sgt. Frank Fazzio at 215-364-5000.