It happened at 7:30 a.m. Thursday on Route 113 at Webb Road.
Images from Chopper 6 HD showed a red SUV and a white sedan, both with extensive front-end damage.
Police tell Action News one person was taken to an area hospital. There was no immediate word on that person's condition.
Route 113 was shut down in both directions between Peck Road and Bell Boulevard as police investigated and road crews worked to remove the vehicles.
Stay with Action News and 6abc.com for more information as it becomes available.