It happened around 6:30 a.m. Saturday on the 600 block of East Broad Street.
Police said the truck went over a curb and crashed into the front of a twin house.
The Quakertown Borough Police Department said no one was injured.
Hours after the crash, authorities continued to work to remove the tractor-trailer from the home.
Shortly after 1 p.m., police opened East Broad Street to traffic again.