It has long been considered one of the most dangerous roadways in America.
PennDOT says between 2013 and 2017, 139 people were killed or seriously injured and there were over 2600 crashes.
Action News spoke to many people who think the cameras are needed.
"After living in Philadelphia all of my life, we desperately need it OK? It's a shame that it's being painted as a money grab," said Gerald Sobeck of Northeast Philadelphia.
Jose Montanez of Mayfair says, "A lot of cars they have a really bad accident over here in this area, so I think it's a really good idea."
By the end of the year, seven to eleven speed cameras will be installed between 9th Street and the Philadelphia county line.
Anyone going 11-20 miles over the 45-mile speed limit would get $100 fine in the mail. 21-30 miles over the limit gets a $125 fine. 31 miles and over equals a $150 fine.
Cindy Ragen likes the idea but, "Even a lower fee would slow people down, I don't think it needs to be that high. They're already getting you at stop signs for $100 a crack."
And Chris Hufnagel of Mayfair says, "I don't really agree with it, Nah. I think it's too high."
"I think it's ridiculous," said Mike Mierzejewski of Northeast Philadelphia. "I think we should go back to old school where more police on the street and maybe they can fine you that way," he added.
But most people supported the idea of speed cameras.
"I think it's a great idea, stop the accidents, I like the plan," said Joe Ciambella of Northeast Philadelphia.
"I guess you shouldn't be going that fast, the speed limit is the speed limit," said Anthony Henderson.
Jose Soto of Northeast Philadelphia says, "I think it should be done because there are too many accidents and a lot of deaths along the boulevard, I think it's great."
Recognizing that motorists may need some time to get used to the speed cameras, there will be a sixty day grace period during which speeders would get a warning notice in the mail. After that, the fines will take effect.