The crash happened around noon Saturday on Casho Mill Road near Munro Road.
Police and medics arrived to find six people hurt and a U-Haul rental truck badly damaged after the truck hit a railroad overpass.
Four of the victims were in the back of the U-Haul.
One of the victims, a 24-year-old woman, was ejected from the upper part of the truck.
She was flown to a nearby hospital in very serious condition.
A 14-year-old boy was in the back of the truck. He suffered lower body injuries. He is in stable condition.
Another victim, an 18-year-old man suffered lower body injuries. He is also stable.
A second 18-year-old man is in stable condition, after suffering a head injury.
The driver, a 42-year-old woman, and a 65-year-old male passenger, are stable.
All were taken to the hospital for treatment.
The cause of the crash is under investigation.