The fire broke out just before 4 a.m. Tuesday on the 5200 block of Whitaker Avenue, near the corner of the Roosevelt Boulevard.
Firefighters said flames were shooting from the first and second floors when they arrived.
One person had to be rescued from the roof.
There is no word on the extent of the injuries.
Crews remained on the scene monitoring hot spots.
There is no word on what might have sparked the blaze.