The accident happened around noon on I-95 northbound, just north of Street Road.
As Chopper 6 flew over the scene, it spotted rescue teams working to free a driver from an SUV that had rammed the back of a box truck.
For a time, emergency responders closed the highway in both directions so a medical helicopter could land to transport the injured.
The northbound lanes were reopened by 1:45 p.m.
