Kevorkian is on parole since being released from prison last year.
He tells The Oakland Press newspaper that he plans to run without party affiliation for the congressional sea now held by Republican Joe Knollenberg.
Kevorkian needs a minimum of 3,000 signatures on nominating petitions to appear as an independent on the November ballot.
"We need some honesty and sincerity instead of corrupt government in Washington," Kevorkian said. He said he would say more about his candidacy next week.
The retired pathologist claims to have helped at least 130 people die from 1990 until 1998 - the year he was charged in the death of Thomas Youk, a 52-year-old man with Lou Gehrig's disease.
Kevorkian has promised not to help in any other assisted suicides and could go back to prison if he did.
There was no immediate response Wednesday to a seeking comment from Kevorkian's attorney, Mayer Morganroth.
Kevorkian was released from prison in June after serving the minimum of his 10- to 25-year sentence for second-degree murder in Youk's death. He earned time off for good behavior and spent eight years and 2½ months behind bars.
Oakland County Prosecutor Dave Gorcyca, whose office was responsible for sending Kevorkian to prison, did not give Kevorkian's candidacy much weight.
"It's probably more of a publicity stunt," Gorcyca said. "To call attention to himself is standard protocol for Jack when he doesn't have the limelight focused on him. I would not consider his candidacy to be a legitimate one."
