Philadelphia welcomed back Allen Iverson, who returned after missing five games to help care for his ill daughter, Messiah. Iverson came off the bench and shot 1 for 7 from the field for four points.
Thaddeus Young led the 76ers with 16 points, and Andre Iguodala added 11.
After a 16-2 run in the second quarter helped build an 11-point halftime lead, the Heat took control with a 17-0 third-quarter run that turned the game into a 69-41 rout.