It happened at 11:15 a.m. Thursday.
Video from Chopper 6 showed damage to two dark-colored pickup trucks, a dark gray sedan, and a silver sedan.
Police say at least one person was seriously injured in the crash and was transported to an area hospital.
That person's name and condition has not be released.
The entire southbound side of the bridge and two lanes of the northbound side were closed as crews worked to clear the wreckage.
All lanes were back open and traffic was flowing freely by 1:00 p.m.
The cause of the crash is under investigation.
