Danes' rep, Jodi Gottlieb, confirms the actress is expecting her first child with husband Hugh Dancy.
The news was first reported on People.com.
The 33-year-old Danes and 37-year-old Dancy met on the set of the film "Evening" and were married in 2009 in France.
The actress first became famous as a teenager on the television drama "My So Called Life," where she won a Golden Globe Award and was nominated for an Emmy. The show was canceled after its first season but developed a cult following.
Dancy will star in the upcoming NBC series "Hannibal," adapted from the novel "Red Dragon" by Thomas Harris.