The fire broke out just before 2:30 a.m. at the Hamilton Court apartments in the 100 block of South 39th Street.
Upon arrival, crews found smoke on the upper floors of the 7-story building. The fire reportedly started on the roof area of the 4th floor.
More than 50 residents, mostly students from Drexel and the University of Pennsylvania were evacuated.
The fire was placed under control just after 3:00 a.m. and there were no reports of any injuries.
Some residents were allowed back in the building in certain areas.
Officials are investigating the cause of the blaze.