After going 1 for 9 in the first three quarters, Holiday got 11 of his 14 points in the fourth to help the Sixers win for the seventh time in 11 games.
Spencer Hawes had 19 points and Thaddeus Young and Damien Wilkins each scored 15 for Philadelphia.
Michael Kidd-Gilchrist had 21 for Charlotte, which has the worst record in the NBA. Gerald Henderson, who had 35 and 34 in his previous two games, finished with 19.
Former Sixers star Allen Iverson came out to a rousing ovation before the opening tip on a night fans received his bobblehead doll. Wearing a Phillies zip-up jacket, cap and black sunglasses, Iverson high-fived fans in the front row. The former NBA MVP sat in a suite and waved to the crowd after a video tribute highlighting his career was shown in the second quarter.
The Sixers are a long way from Iverson's glory days. They entered the season with high expectations after the acquisition of Andrew Bynum, but he didn't play one game because of knee injuries and the Sixers are five losses away from playoff elimination.
Royal Ivey hit a 3-pointer to give the Sixers an 82-80 lead near the midpoint of the fourth quarter and they never trailed again. Holiday sliced through the lane and threw down a left-handed jam over Bismack Biyombo and Josh McRoberts to extend the lead to 91-84.
Kemba Walker answered with consecutive baskets to get the Bobcats within 91-88. Holiday then nailed a jumper and added a layup to make it 95-90.
Down 11 early in the second quarter, the Sixers reeled off 11 straight points. Ivey's 3-pointer tied it at 33. Hawes hit a 3 a few minutes later for a 46-42 lead and Philadelphia was up three at halftime.
Charlotte took a 13-point lead in the first quarter following an 11-2 run. Kidd-Gilchrist had seven of those points, including a dunk to finish it off.
The Pargo brothers - Charlotte's Jannero and Philadelphia's Jeremy - didn't get to go 1-on-1. Jeremy didn't enter the game. Jannero had 11 points.