The fire broke out in a home on Bodine Avenue in Burlington Township just before 2:00 a.m. Sunday.
Investigators say a meth lab was set up in the home.
Firefighters knocked down the fire then retreated from the home to avoid being overcome by the fumes.
A man and a woman living in the house were transported to Virtua Hospital for smoke inhalation.
Several county hazardous material units were called out to the scene to decontaminate at least a half dozen firefighters outside of the home.
The incident remains under investigation.