The blaze appears to have started in a second floor apartment above a store on the 2000 block of East Cambria Street.
The fire quickly spread to the house next door where the two victims lived. The woman and another man jumped from second floor windows.
The woman has been identified as Loretta Cannon, 58, of the 2100 block of East Cambria. She was pronounced dead at the hospital.
The man who jumped is not seriously injured.
A second man was seriously burned in the fire and is currently listed in stable condition at a local hospital.
Neighbors told Action News that they saw a young man running from the scene. Police are questioning him.
The mother of the young man said that her son lived with the couple until yesterday, when he moved out after getting into an argument with them.
"They're always fighting in that house," she said. "Always carrying on every day, every day. An argument every day."
The fire marshal is looking for the cause of the blaze. Firefighters say there were no working smoke alarms in the home.
The woman is the 22nd person to die in a city fire this year.
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