"The whole thing makes me feel badly," Shatner said in the video. "Poor man. There is such a sickness there. It's so patently obvious that there is a psychosis there. I don't know what his original thing about me was. I have no idea."
Takei and Brad Alman tied the knot Sept. 15. "Star Trek" alums Nichelle Nichols and Walter Koenig - who played Uhura and Chekhov, respectively - were among the attendees at the multicultural ceremony at the Japanese American National Museum. Takei and Altman had previously stated that Shatner was invited to their wedding, but he never RSVPed.
"It is unfortunate that Bill was unable to join us for our wedding as he indeed was invited to attend," Takei responded. "It is our hope that at this point he joins us in voting no on Proposition 8, which seeks to eliminate the fundamental right for same-sex couples to marry in California."
Shatner said he felt he never knew Takei when they worked together on the original TV series and later in the "Star Trek" films.
The "Boston Legal" co-star also attacked Takei's decision to come out of the closet later in life, saying "Who cares? Be gay. Don't be gay. That's up to you, George."