Safety Antoine Bethea and defensive back Raheem Brock will not play because each has a broken hand. Cornerback Kelvin Hayden is out with a hamstring injury, and defensive end Robert Mathis is out with a bruised thigh.
Also missing the game will be backup quarterback Jim Sorgi and tight ends Gijon Robinson and Tom Santi.
The Colts also re-signed guard Tom Pestock and waived offensive lineman Corey Hilliard.
Get Action News on your website
Follow Action News on Facebook
Click here to get the latest Philadelphia news and headlines from across the Delaware and Lehigh valleys.