Concert promoters AEG Europe said Wednesday the star of such musicals as "Mary Poppins" and "The Sound of Music" will appear at London's 02 Arena on May 8.
Andrews had non-cancerous throat nodules removed in 1997. The operation initially left her unable to sing.
Andrews has since starred in such films as "The Princess Diaries" and as the voice of Queen Lillian in the "Shrek" series.
Tickets go on sale Thursday.
Andrews says in a statement that "to perform once again in my homeland on the London stage will be a wonderful moment - it is where it all began for me, and I am so excited to be able to share a brand new work with audiences."