Pittsburgh improved to 5-0 in shootouts this season, while the Flyers fell to 2-2. Crosby is 5-for-5 in shootout goals. The defending Stanley Cup champions recorded their 10th win in 13 games. The Flyers lost for the 12th time in 15 games.
The Flyers struck first when Jeff Carter's shot was stopped Marc-Andre Fleury, and the rebound deflected off Sergei Gonchar into the net.
Pittsburgh answered 1:33 later on Bill Guerin's power-play goal. The right wing collected Chris Kunitz's rebound and beat Brian Boucher. Dan Carcillo's high-sticking penalty gave the Penguins the advantage.
The teams also traded goals in the second period. Claude Giroux gave the Flyers the lead when he picked up Carcillo's rebound during a power play, but Crosby evened the score with a slap shot from the face off circle.
Fleury stopped 31 shots, and Boucher made 28 saves.
The teams played for the second time in three days. The Penguins won 6-1 in Pittsburgh on Tuesday night in a game marred by fights between Arron Asham and Mike Rupp, Riley Cote and Eric Godard, and Carcillo and Craig Adams in the opening 5:33, and players from both sides antagonized the other throughout.
After the Tuesday loss, Flyers captain Mike Richards said the team wasn't "playing with enough heart right now to win."
The bad blood goes back to Pittsburgh's 5-4 win in Philadelphia on Oct. 8, when the Penguins accused Philadelphia's Scott Hartnell of biting defenseman Letang's finger. Thursday's game also had on-ice jawing and some pushing and shoving.
NOTES: Crosby has 10 goals and seven assists in his last eight games.