At least 51 senators have announced they will back Kagan in the vote expected Thursday. President Barack Obama named the 50-year-old solicitor general to succeed retired Justice John Paul Stevens.
She's drawn the support so far of all but one Democrat - Sen. Ben Nelson of Nebraska - plus one independent and five Republicans.
Arkansas Democratic Sens. Blanche Lincoln and Mark Pryor on Wednesday became the latest Democrats to announce that they, too, plan to vote "yes."
A parade of Republicans are taking to the Senate floor to denounce Kagan as a political activist who has no place on the bench.