Arrested were 25-year-old Jet Inferno and 25-year-old Tabitha Vickers.
Police went to their home in the 28000 block of Basin Road in Millsboro on Tuesday.
Inside, officers say they found pot growing in the attic and a bathroom. The marijuana plant in the bathroom was six feet tall, police said.
Police say they also found guns and drug paraphernalia in the home.
Inferno and Vickers were released at $16,500 secured bond.
The couples' roommates, 22-year-old Joshua Hilbert and 20-year-old Anna Dean were also arrested for drug possession and released on their own recognizance.
Also charged with drug possession were 19-year-old Allen Schneider and 20-year-old Devan Baull.