His late-night run on TBS hosting "Conan" will kick off with Seth Rogen and musician Jack White on Monday, Nov. 8, the network has announced.
Tuesday's show will include guests Tom Hanks, "30 Rock" regular Jack McBrayer and Soundgarden.
"Mad Men" star Jon Hamm stops by on Wednesday, and Thursday, Conan will greet Michael Cera and Julie Bowen.
For nearly 20 years, O'Brien was a fixture at NBC, but he left last January after just a few months as host of "The Tonight Show."
His new Los Angeles-based show will air Mondays through Thursdays at 11 p.m. Eastern.
His very first guest might be decided by an online poll, which offers unlikely choices like Pope Benedict XVI.