Jay Bowie had 14 points for Marist (0-1), which extended Division I's longest losing streak to 19 games.
Villanova (2-0) had an easy time against the overmatched Red Foxes, who were 1-29 last season. The Wildcats have become NCAA tournament regulars under coach Jay Wright, and reached the Final Four two years ago. They have won 39 straight games at The Pavilion.
Villanova used a 19-1 run to take a 24-9 lead in the first half, and never looked back. Marist went 16 straight possessions without a field goal during that stretch. Wayns and Cheek each scored seven points during the run.